Background

TI: A reduction in the correlation dimension of heartbeat intervals precedes imminent ventricular fibrillation in human subjects.

AU: Skinner-JE; Pratt-CM; Vybiral-T

AD: Department of Neurology, Baylor College of Medicine, Houston, TX.

SO: Am-Heart-J. 1993 Mar; 125(3): 731-43

LA: ENGLISH

CP: UNITED-STATES

AB: Reduced reflexive control of heartbeat intervals occurs with advanced heart disease and is an independent risk factor for mortality. Based on a previous study of experimental myocardial infarction in pigs, we hypothesized that a deterministic measure of heartbeat dynamics, the correlation dimension of R-R intervals (D2), may be a better predictor of risk than a stochastic measure, such as the standard deviation (SD). We determined the point estimates of the heartbeat D2 (i.e., PD2s) in Holter electrocardiographic recordings from 11 high-risk patients who manifested ventricular fibrillation (VF) during the recording and in high-risk controls having only nonsustained ventricular tachycardia (14 patients) or premature ventricular complexes (13 patients). We found that PD2 reduction (i.e., PD2s 1.2) precedes lethal arrhythmias by hours, but is not reduced in high-risk controls (p 0.001; sensitivity, 91%; specificity, 85%). Heartbeat SD did not discriminate among the patients. Thus PD2 of heartbeat intervals may provide an important diagnostic test and early warning sign of VF.

MIME: Algorithms-; Death,-Sudden,-Cardiac-epidemiology; Extrasystole-epidemiology; Middle-Age; Predictive-Value-of-Tests; Risk-Factors; Sensitivity-and-Specificity; Stroke-Volume-physiology; Tachycardia,-Ventricular-epidemiology; Time-Factors; Ventricular-Fibrillation-diagnosis